Pitt Scientists Lead Consensus Guidelines for Thyroid Cancer Molecular Tests

Posted on July 6, 2015

PITTSBURGH, July 6, 2015 – University of Pittsburgh Cancer Institute (UPCI) scientists recently led a panel of experts in revising national guidelines for thyroid cancer testing to reflect newly available tests that better incorporate personalized medicine into diagnosing the condition.

Their clinical explanation for when to use and how to interpret thyroid cancer tests is published in the July issue of the scientific journal Thyroid. The American Thyroid Association is revising its 2015 Guidelines for Thyroid Nodule and Thyroid Cancer Management to direct doctors to the scientific publication.

“Minimally invasive molecular testing for thyroid cancer has improved by leaps and bounds in the last several years,” said co-author Robert L. Ferris, M.D., Ph.D., professor and chief of the Division of Head and Neck Surgery in Pitt’s School of Medicine. “But different tests perform differently and, therefore, need to be interpreted carefully to make the best decisions regarding extent of surgery for patients with thyroid nodules. Our goal with this analysis is to give clinicians a clear understanding of what each type of test can tell them and when to use them to determine the best course of treatment.”

Cancer in the thyroid, which is located just below the “Adam’s apple” area of the neck, is the fifth most common cancer diagnosed in women. Thyroid cancer is one of the few cancers that continues to increase in incidence, although the five-year survival rate is 97 percent.

UPCI, partner with UPMC CancerCenter, has been a national leader in developing personalized genetic tests for thyroid cancer that have spared patients repeat or unnecessary surgeries. A low-cost test called ThyroSeq, developed by a team led by Yuri Nikiforov, M.D., Ph.D., director of Pitt’s Division of Molecular and Genomic Pathology, allows pathologists to simultaneously test for multiple genetic markers of thyroid cancer using just a few cells collected from the nodule.

This allows doctors to “rule-in” a specific cancer diagnosis with a high degree of certainty, without a biopsy to remove a large portion of the thyroid, which would then have to be followed with a second surgery if cancer is detected to remove the entire gland. As Dr. Nikiforov’s group added more genetic sequences to the ThyroSeq test to create a larger and more sensitive version of the test, it is now also performing as a “rule-out” test that can tell doctors with a high degree of certainty that a patient does not have cancer.

Other available tests use different technology to serve as accurate “rule-out” tools, but do not have the high sensitivity needed to also reliably “rule-in” cancer. And, in some cases, the accuracy of the “rule out” tests depends on the prevalence of cancer in the patients seen by each individual cancer institute. This is critical because clinicians must know this rate at their institution to correctly calculate the accuracy of “rule-out” test results for each patient.

In addition to Dr. Ferris and co-author Sally E. Carty, M.D., who is professor and chief of the Division of Endocrine Surgery in Pitt’s School of Medicine and co-director of the UPMC/UPCI Multidisciplinary Thyroid Center, the panel reviewing the tests was a multidisciplinary group from a dozen institutions in the U.S. and Canada.

“This was a very innovative and collegial initiative,” said Dr. Carty.  “Through an objective review of the existing tests and the scientific literature characterizing their performance, we are seeking to help clinicians make the best decisions for their patients.”

Dr. Ferris agrees, noting that “this is an exciting time in personalized medicine, and these tests give us the ability to not only better diagnose and treat thyroid cancer, but also significantly reduce surgeries for people who don’t have cancer.”

Additional authors on this publication are Zubair Baloch, M.D., Ph.D., University of Pennsylvania Medical Center; Victor Bernet, M.D., Mayo Clinic; Amy Chen, M.D., Emory University; Thomas J. Fahey III, M.D., New York Presbyterian Hospital; Ian Ganly, M.D., Ph.D., and Ashok Shaha, M.D., both of Memorial Sloan-Kettering Cancer Center; Steven P. Hodak, M.D., and Kepal N. Patel, M.D., both of New York University Medical Center; Electron Kebebew, M.D., National Cancer Institute; David L. Steward, M.D., University of Cincinnati Medical Center; Ralph P. Tufano, M.D., Johns Hopkins University; and Sam M. Wiseman, M.D., St. Paul’s Hospital & University of British Columbia.

American Academy of Periodontology to Hold Annual Meeting in Orlando

Posted on July 2, 2015

CHICAGO–July 2, 2015–The American Academy of Periodontology (AAP) is set to hold its 101st Annual Meeting from November 14-17, 2015, at the Gaylord Palms Resort & Convention Center in Orlando, Florida. Offering over 25 hours of continuing education credits, the 101st Annual Meeting provides more than 40 different courses relevant to periodontal care, including treatment technique advances, emerging technologies, scientific advancements, practice development and management, clinical applications, and more.

“With thousands of periodontists, hygienists, dental students, and researchers in one place, the annual AAP meeting provides an opportunity to learn, share, and network with professionals from around the world,” remarked Dr. Joan Otomo-Corgel, president of the AAP. “Attendees can tailor their schedules with course selections that are right for them. Sessions range from single topics in periodontics to multidisciplinary symposia that explore diverse clinical solutions—and everything in between! We strongly encourage all dental professionals who are interested in learning about the latest advances in periodontics and understanding how partnering with periodontal colleagues can benefit patient care to register now.”

Attendees of the AAP’s 101st Annual Meeting can choose from a diverse selection of programming organized into eight program tracks that focus on various aspects of periodontics, including:

·       Imaging and Emerging Technologies

·       Implants

·       Interdisciplinary Therapy

·       Periodontic-Systemic Relationships

·       Periodontal Plastic/Oral Reconstructive Surgery

·       Practice Development and Management

·       Regenerative/Tissue Engineering

·       Treatment of Inflammatory Periodontal Diseases

Each track provides a number of in-depth educational sessions, exceptional hands-on workshops, and clinical technique showcases presented by leading industry experts and thought leaders. In addition, the Corporate Forums will feature presentations from leading periodontal vendors, and the Exhibit Hall will feature over 150 companies showcasing the latest industry products and services.

Some highlights of the 2015 AAP Annual Meeting include the following:

Opening General Session:A compelling educational experience entitled, “Facial Reconstruction and Facial Transplantation: Achieving Success Though a Team Effort”, presented by renowned facial transplant experts Dr. Lawrence Brecht and Dr. Eduardo Rodriguez

AAP/AAP Foundation and Osteology Foundation Symposium: A jointly developed program from the AAP, AAP Foundation, and Osteology Foundation entitled, “Current Technologies for Hard and Soft Tissue Oral Regeneration”

Dental Hygiene Symposium:Geared exclusively toward dental hygienists, this special series of lectures recognizes the valuable role of hygienists in oral healthcare by providing sessions on the most current topics in periodontics, including perio-systemic health inter-relationships, periodontal regeneration, peri-implant disease, and soft tissue augmentation

To register for the 2015 Annual Meeting or for more information, please visit www.perio.org/meetings, call 1-800-282-4867 ext. 3213, or email meetings@perio.org

Hispanic Dental Association Partners with W.K. Kellogg Foundation

Posted on July 2, 2015

AUSTIN, TEXAS. – The 2015 National Hispanic/Latino Oral Health Education Campaign begins on June 30th . The project is funded by a $50,000 grant from the W.K. Kellogg Foundation of BattleCreek, Mich.

“As the Hispanic Community continues to grow, oral health disparities are not being addressed at a pace that keeps up with the increase in the population size. We look forward to an impactful partnership where we can empower the public with culturally appropriate oral health information,” voiced Dr. Vidal Balderas DDS, President of the Hispanic Dental Association.

Campaign efforts will be national in scope, but highlight and focus in cities where HDA has a professional chapter and be augmented through its 34 Dental Student Chapters. The focus centers on 3 key components;

1. Educate dental oral health professionals regarding the oral health needs of the underserved population in their communities suffering from untreated dental disease.

2. Educate private practitioners on how to strengthen and expand the public/private health safety net through new innovative oral health providers and workforce models.

3. Educate the Hispanic/Latino population on disease prevention and dental health through bi-lingual messaging and materials.

"Our partnership and campaign will shine a light on communities where oral health disparities continue to be an issue. From a health equity standpoint, we hope that this will be a catalyst for conversations and action throughout our communities that receive little to no oral health information, and are disproportionately impacted by the inequities in access to information and services,” said David Pena, Jr., Executive Director of the Hispanic Dental Association.

“This campaign effort pursues authentic engagement with communities, and has the potential to be the strongest and most effective pathway to community-led solutions for improving the oral health of Latino children and families,” said Dr. Alice Warner, director of policy with the W.K. Kellogg Foundation.

eHuman Digital Anatomy Releases Head and Neck Anatomy Atlas

Posted on July 2, 2015

Fremont, CA (PRWEB) March 20, 2015 eHuman Digital Anatomy, the industry leader in next generation dental education software announced today the release of their latest product, Head and Neck Anatomy Atlas. Head and Neck Anatomy Atlas is a growing encyclopedic resource covering human anatomy, with extensive 3D anatomic resources, self-assessment quizzes with reference libraries and games that test the knowledge acquired through the use of the programs 3D resources.

Head and Neck Anatomy Atlas include the following interactive sections: 

  •     Skull Osteology

  •     Temporomandibular joint anatomy

  •     Bony landmarks of the skull

  •     Muscles and Ligaments

  •     Innervations

  •     Arterial supply

  •     Venous drainage

  •     Edentulous anatomy

Within each section, there are interactive 3D programs that allow users to rotate, zoom, and pan 3D anatomic specimens derived from high resolution CT scans so they can visualize and learn critical relationships between the structures. There are also 3D animations and video clips that allow 3D navigation through objects, seeing their cross-sectional form.

A unique feature of the program is the ability to 3-dimensionally view the temporomandibular joint and skull. Each of the individual components of the TMJ can be visualized and interactively manipulated. The program also has the ability to “Build a Temporomandibular Joint”, a feature that allows users to view any of the hard or soft tissue components of the joint either singly or in combination with any number of the other components.    

“I have used the program for several years to teach students in different parts of the world and have found it to be an extremely valuable learning resource" said, Dr. Charles Goodacre, Professor of Restorative Dentistry, Loma Linda University School of Dentistry.

Head and Neck Atlas Anatomy includes several specially designed “Quizzes with Reference Libraries” that allow users to test the knowledge they have acquired by viewing the 3D programs and video clips. The Reference Library section of each quiz provides an extensive resource of visual and textual information that can be accessed while the quiz is being taken to find the answer to a question after which the user can then return to the quiz and continue answering the questions.

Additionally, uniquely designed games have been included in the program to provide users with the ability to assess the speed and accuracy with which they can recall the visual information learned through the “3D Programs” and the “Quizzes with Reference Libraries”.    

For more information or to purchase eHuman’s Head and Neck Anatomy, please visit:http://www.ehuman.com/products/HeadandNeckAnatomy

Oral Health America Announces 14th Annual NSTEP Slogan Contest

Posted on July 1, 2015

 

CHICAGO, July 1 — Oral Health America (OHA) is pleased to announce the launch of its 14th annual NSTEP® (National Spit Tobacco Project) slogan contest. Teaming up with Little League® Baseball and Softball, the contest calls on players ages 8-14 to create a compelling ten-word phrase describing the dangers of spit tobacco for a chance to win a trip to the Little League Baseball® World Series.

In addition to its long history with baseball, spit tobacco is used more frequently by young people—almost half (46%) of new users start before they reach the age of 18. Spit tobacco is linked to cancer of the mouth, throat, tongue, stomach and esophagus, mouth lesions, receding gums, tooth decay and tooth loss. Through the slogan contest, OHA and Little League reach tens of thousands of young people each year with the message that spit tobacco is dangerous and should be avoided.

“Little League is committed to providing proper health and wellbeing for children throughout the world,” said Stephen D. Keener, President and CEO of Little League Baseball and Softball. “Smokeless tobacco has no place whatsoever in the lives of our youth. We applaud Oral Health America’s effort in keeping children away from smokeless tobacco and starting the conversation with so many parents about the dangers associated with its use. The NSTEP Slogan Contest is a great way to engage children and their families and educate them on the risks associated with smokeless tobacco.”

“Every summer we hear from parents across the country who use the slogan contest as an opportunity to talk to their children about spit tobacco for the first time,” said OHA President and CEO Beth Truett. “All tobacco products are harmful and we look forward to reaching even more young people with this important message.”

For the first time contest participants will be able to submit their slogans online by filling out a simple form. The winner will receive an all-expense paid trip to the Little League Baseball World Series in Williamsport, Pa. and a $500 cash prize. In addition, OHA will make a $500 donation to the player’s Little League organization. For more information about the contest or to submit a slogan, please visit nstep.org/contest.

AAE and AAOMR Issue Position Statement on 3-D Imaging in Endodontics

Posted on July 1, 2015

CHICAGO – In response to new developments and research indicating the effectiveness of 3-D imaging for endodontic diagnosis and treatment, the American Association of Endodontists and the American Academy of Oral and Maxillofacial Radiology have issued a revised position statement on the use of cone beam-computed tomography in endodontics. The joint statement is an update to a 2010 position on CBCT use in endodontics.

An AAE-AAOMR committee reviewed the scientific literature from the past five years, and updated the position statement to include specific recommendations for the appropriate use of CBCT. The statement emphasizes that CBCT should not be used routinely for endodontic diagnosis or screening purposes in the absence of clinical signs and symptoms, and provides 11 specific recommendations and supporting evidence for when CBCT should be considered the imaging modality of choice. The statement is consistent with principles of ALARA—keeping patient radiation doses "as low as reasonably achievable," and notes that the patient's history and clinical examination must justify the use of CBCT by demonstrating that the benefits to the patient outweigh the potential risks.

"Endodontists continue to have excellent results with two-dimensional radiography," said AAE President Dr. Terryl A. Propper. "However, limited field of view CBCT does have a place in endodontics when dealing with more complex cases, which are reflected in the position statement. Our goal is to help AAE members and general dentists determine where it fits for them."

"Dental imaging is interlaced with endodontics not only for accurate diagnosis but for periodic evaluation of certain treatment outcomes," said AAOMR President Dr. Christos Angelopoulos. "Complex cases may require the use of advanced imaging modalities such as CBCT for proper diagnoses, although advanced imaging may not be necessary as a routine diagnostic tool. The collaboration of AAOMR and the AAE aims to provide guidance to general dentists and endodontists based on the available evidence. The main goal of the two organizations is simply to guide practitioners toward 'best practice'."

The current position statement was drafted by a special joint committee of leading experts in the area of CBCT in endodontics. Each organization appointed four representatives. Dr. Mohamed I. Fayad of the University of Illinois at Chicago, appointed by the AAE, and Dr. Madhu K. Nair of the University of Florida, appointed by the AAOMR, served as co-chairs of the committee. AAE Members Drs. Craig S. Hirschberg, Martin D. Levin and Richard A. Rubinstein also served on the committee, along with Drs. Sevin Barghan, Erika Benavides and Axel Ruprecht from the AAOMR. The position statement is available at www.aae.org/guidelines.

Dental Industry Leaders Show Commitment to Children's Oral Health as America's Toothfairy Board Members

Posted on July 1, 2015

(Charlotte, NC, July 1, 2015) –America's ToothFairy: National Children’s Oral Health Foundation® announced today the members of its Board of Directors for fiscal year 2016. Under the chairmanship of Henk van Duijnhoven, Senior Vice President at Danaher Corporation and its dental segment, KaVo Kerr Group, the America's ToothFairy Board of Directors is comprised of dedicated leaders of national and international organizations, universities and corporations concerned with improving children’s health and building healthier communities.

Alongside Mr. van Duijnhoven, other Board officers include Vice President James Ingebrand, President and General Manager of 3M ESPE Dental Division, Treasurer Paul A. Guggenheim, President of Patterson Dental Supply, Inc., and Secretary Robert Size, Senior Vice President of DENTSPLY International.

Gavin Shea, Senior Director of Sales and Marketing for Wells Fargo Practice Finance, was newly elected to the Board and will serve a three-year term.

"We are proud to have assembled such an esteemed group of industry leaders and practitioners to guide the continued growth and development of this organization," said Fern Ingber, America's ToothFairy President and CEO. "Our Board members are enthusiastic supporters and advocates who, despite significant personal and professional obligations, have made a strong commitment to expand the mission of America's ToothFairy to millions more underserved children. We are very grateful for their passion, dedication and support."

Tufts: Sugary Drinks Linked to High Death Tolls Worldwide

Posted on July 1, 2015

BOSTON (June 29, 2015, 4 pm ET) — Consumption of sugary drinks may lead to an estimated 184,000 adult deaths each year worldwide, according to research published today in  the journal Circulation and previously presented as an abstract at the American Heart Association Council on Epidemiology and Prevention in 2013.

“Many countries in the world have a significant number of deaths occurring from a single dietary factor, sugar-sweetened beverages. It should be a global priority to substantially reduce or eliminate sugar-sweetened beverages from the diet,” said Dariush Mozaffarian, M.D., Dr.P.H., senior author of the study and dean of the Friedman School of Nutrition Science & Policy at Tufts University in Boston.

In the first detailed global report on the impact of sugar-sweetened beverages, researchers estimated deaths and disabilities from diabetes, heart disease, and cancers in 2010. In this analysis, sugar sweetened beverages were defined as any sugar-sweetened sodas, fruit drinks, sports/energy drinks, sweetened iced teas, or homemade sugary drinks such as frescas, that contained at least 50 kcal per 8oz serving. 100 percent fruit juice was excluded.

Estimates of consumption were made from 62 dietary surveys including 611,971 individuals conducted between 1980 and 2010 across 51 countries, along with data on national availability of sugar in 187 countries and other information.  This allowed capture of geographical, gender and age variation in consumption levels of sugar-sweetened beverages in different populations.  Based on meta-analyses of other published evidence on health harms of sugar-sweetened beverages, the investigators calculated the direct impact on diabetes and the obesity-related effects on cardiovascular disease, diabetes and cancer.

In 2010, the researchers estimate that sugar-sweetened beverages consumption may have been responsible for approximately:

133,000 deaths from diabetes

45,000 deaths from cardiovascular disease

6,450 deaths from cancer

“Some population dietary changes, such as increasing fruits and vegetables, can be challenging due to agriculture, costs, storage, and other complexities. This is not complicated. There are no health benefits from sugar-sweetened beverages, and the potential impact of reducing consumption is saving tens of thousands of deaths each year,” Mozaffarian said.

The impact of sugar-sweetened beverages varied greatly between populations. At the extremes, the estimated percentage of deaths was less than 1 percent in Japanese over 65 years old, but 30 percent in Mexican adults younger than 45.

Of the 20 most populous countries, Mexico had the highest death rate attributable to sugar-sweetened beverages with an estimated 405 deaths per million adults (24,000 total deaths) and the U.S. ranked second with an estimated  125  deaths per million adults (25,000 total deaths).

About 76 percent of the estimated sugar-sweetened beverage-related deaths occurred in low- or middle-income countries.

In nations of the Caribbean and Latin America, such as Mexico, homemade sugary drinks (e.g. frescas) are popular and consumed in addition to commercially prepared sugar-sweetened beverages. “Among the 20 countries with the highest estimated sugar-sweetened beverage-related deaths, at least 8 were in Latin America and the Caribbean, reflecting the high intakes in that region of the world,” said Gitanjali Singh, Ph.D., lead author of the study and a research assistant professor at the Friedman School.

Overall, in younger adults, the percent of chronic disease attributed to sugar-sweetened beverages was higher than the percent in older adults.

“The health impact of sugar-sweetened beverage intake on the young is important because younger adults form a large sector of the workforce in many countries, so the economic impact of sugar-sweetened beverage-related deaths and disability in this age group can be significant. It also raises concerns about the future. If these young people continue to consume high levels as they age, the effects of high consumption will be compounded by the effects of aging, leading to even higher death and disability rates from heart disease and diabetes than we are seeing now,” Singh said.

Other co-authors are Renata Micha, Ph.D.; Shahab Khatibzadeh, M.D.; Stephen Lim, Ph.D.; and Majid Ezzati, Ph.D. Author disclosures are on the manuscript.

Singh was supported by a training grant from the  National Institute of Diabetes and Digestive and Kidney Diseases (DK007703) and a K00/R00 Pathway to Independence Award from the National Heart, Lung and Blood Institute (1K99HL124321).  Initial data collection for this work was supported by a grant from The Bill & Melinda Gates Foundation to the 2010 Global Burden of Diseases study. 

Singh GM, Micha R, Khatibzadek S, Lim S, Ezzati M, and Mozaffarian, D. “Estimated global, regional, and national disease burdens related to sugar-sweetened beverage consumption in 2010.”  Circulation. Published online ahead of print 06-29-15. DOI:10;1161/CirculationAHA.1140101636

IADR/AADR Publish Proceedings: Oral Health Inequalities in Africa and the Middle-East Region

Posted on June 30, 2015

Alexandria, Va., USA – The International and American Associations for Dental Research (IADR/AADR) have published the proceedings from the IADR symposium titled “Oral Health Inequalities in Africa and the Middle-East Region,” which took place June 24, 2014, in Cape Town, South Africa. This symposium was held in conjunction with the 92nd General Session of the IADR. The proceedings are published in the July issue of the IADR/AADR Advances in Dental Research, an E-supplement to the Journal of Dental Research. Eino Honkala, Kuwait University, served as a guest editor of this Advances issue. 

The symposium prepared a suitable situation analysis of the inequalities related to oral health in the Africa/Middle East Region by forming task groups for the different areas suggested by the IADR Global Oral Health Inequalities Research Network. The Task Groups identified and reviewed the existing knowledge bases and key gaps in knowledge and regional variations; priorities for both basic and applied research; and a five-year research agenda and goals for improvements in oral health and reducing inequalities in the IADR Africa/Middle East Region, with particular reference to inequalities between and within countries. 

“These reviews will be important to policymakers for investments in research, capacity building, risk factor reduction and health promotion aimed at reducing oral health inequalities in Africa and the Middle East,” said Guest Editor Eino Honkala. A companion editorial to the Advances issue can be found in the July Issue of the Journal of Dental Research authored by Dr. Honkala as well as Drs. Aubrey Sheiham and David Williams highlighting the impact this work is having on the Africa and Middle East Region. 

The symposium was made possible through support from the Borrow Milk Foundation and the IADR Regional Development Program. To read the proceedings from the Oral Health Inequalities in Africa and the Middle-East Region symposium, please visit http://adr.sagepub.com or contact Ingrid L. Thomas at ithomas@iadr.org to request PDFs of the articles. 

DENTSPLY Expands TruExpressionTM Denture Teeth

Posted on June 30, 2015

York, PA – DENTSPLY Prosthetics has announced the expansion of its popular TruExpression tooth line with new Highly Characterized mould forms. TruExpression denture teeth are constructed of durable MXL material, a highly cross-linked polymer, which delivers good wear resistance in both partial and full-denture cases. The new mould series is now available in 9-upper/6-lower anterior mould and 12-upper/lower posterior mould forms and delivers these benefits:

Features: 

-Larger mould sizes (up to 50%)

-Wide food table

Long crown forms

-Greater aesthetic details

Benefits:

-Greater selection to match natural anatomy

-Improved occlusal function

-Natural dentition appearance

-Realistic occlusal details

TruExpression Denture Teeth offer a “Custom Deluxe” solution that provides “True-to-Life” shade blending that mimics natural dentition for the patient seeking the next step in improved dental appearance and functional durability.

For more information or to order Dentsply TruExpression teeth and the new highly characterized mould forms, please ask your DENTSPLY Prosthetics Sales Representative or contact DENTSPLY Prosthetics directly at 1-800-243-1942. TruExpression denture teeth are available for purchase via a broad distributor network – ask you dealer.

DENTSPLY International Inc. is a leading manufacturer and distributor of dental and other consumable medical device products. The Company believes it is the world's largest manufacturer of consumable dental products for the professional dental market. For over 115 years, DENTSPLY's commitment to innovation and professional collaboration has enhanced its portfolio of branded consumables and small equipment. Headquartered in the United States, the Company has global operations with sales in more than 120 countries. Visit www.dentsply.com for more information about DENTSPLY and its products.

© 2015 AEGIS Communications | Privacy Policy