Development of Drugs for Local Treatment of Oral Conditions

Posted on June 27, 2016

Seoul, Republic of Korea – At the 94th General Session & Exhibition of the International Association for Dental Research, researcher W. Peter Holbrook, University of Iceland, presented a study titled “Development of Drugs for Local Treatment of Oral Conditions.” The IADR General Session was held in conjunction with the 3rd Meeting of the IADR Asia Pacific Region and the 35th Annual Meeting of the IADR Korean Division.

Several medications commonly prescribed for oral mucosal administration are actually intended for transdermal application. Many conditions affecting the oral mucosa require frequent or long-term treatments and some treatments are systemically applied. Clinical resistance and patient intolerance of such treatments may develop. There is thus a constant need to address these problems through the development of less side-effect prone drugs.

Researchers at the University of Iceland have developed several new formulations for topical treatments of oral mucosal conditions and carried out appropriate clinical trials. The main area of this research has been the inhibition of matrix metallo-proteinase activity using topical doxycycline, initially in order to treat aphthous ulceration. The antimicrobial compound monocaprin was also tested for activity against herpes virus and, in combination with doxycycline, was developed in an active formulation for treating cold sores (canker sores). Monocaprin also has anticandidal activity that has been evaluated among geriatric patients with denture stomatitis.

Topical application of doxycycline was very effective in promoting healing of mucosal lesions. Monocaprin reduced counts of Candida rapidly and significantly. The results of these clinical studies have been very promising when compared to the conventional treatments available in Iceland and abroad. Stability of the active components has recently been effectively addressed and current research is aimed at different types of drug delivery systems in order to optimize drug delivery to the local mucosal site. This includes drug release time and mucoadhesive capacity of the formulation, thereby attempting to develop more disease-specific drug delivery systems.

This research was funded by grants from the Icelandic Research Council (Rannis) and the University of Iceland.

Researchers Study HPV Infection in Leukoplakia in the Last Decade

Posted on June 27, 2016

Seoul, Republic of Korea – At the 94th General Session & Exhibition of the International Association for Dental Research, researcher Jonas Sundberg, University of Gothenburg, Sweden, presented a study titled “Increased Expression of p16 in Oral Leukoplakia the Last Decade.”

During the last two decades an increase in incidence of oropharyngeal carcinomas related to human papilloma virus (HPV) infection has been reported. Although a casual association between lekoplakia, oral cancer, and HPV has been suggested in several reports, no conclusive evidence has been presented. To assess the presence of HPV, the tumor suppressing protein p16 is commonly used as a surrogate marker for HPV infection. The aim of the present study is to investigate whether p16 expression in tissue specimens from lekoplakia has increased during the last decade, which may indicate an increase in incidence of oral HPV infection.

A patient cohort with tissue specimens obtained between 1992 and 2001 and a cohort where specimens were obtained between 2011 and 2015 and with histopathological diagnoses of benign hyperkeratosis or hyperkeratosis with dysplasia were examined. Immunohistochemistry was performed using a monoclonal antibody (clone E6H4; Roche Ltd) visualizing p16. Digitalized images of sections were obtained and a semiquantitative scale (0-5) was used to enumarate p16 expression in oral epithelium.

In the 2011-2015 cohort lekoplakia epithelium showed a significant increase (P = .02) in grade 4 and 5 p16 expression in comparison with lekoplakia epithelium in the 1992-2001 cohort. In lekoplakia presenting with dysplasia, grade 4 and 5 p16 expression also increased significantly (P = .0001) over time when comparing the cohorts. The results indicate an increase in HPV infection in lekoplakia during the last decade. Researchers are further investigating the presence of HPV DNA utilizing polymerase chain reaction is presently undertaken.

This research was funded by the Regional Research Council, Region Västra Götaland, Assar Gabrielsson Foundation and the Swedish Dental Society.


America’s ToothFairy Announces 2016 Youth of the Year Award Winners

Posted on June 27, 2016

Charlotte, NC – June 24, 2016) – America’s ToothFairy: National Children’s Oral Health Foundation® is proud to announce its 2016 Youth of the Year Award winners. This award recognizes high school students who have made exceptional efforts to raise awareness of the importance of children’s oral health and wellness in their community.

This year’s winners, Sabrina Herbert, Sara Rodriguez, Iris Valadez, and Caroline Vasquez, are members of the HOSA: Future Health Professionals chapter at Southwest High School in El Centro, CA, and actively participate in the #MySmileMatters Youth Movement. Launched in 2003, #MySmileMatters is an initiative of America’s ToothFairy engaging nearly 600,000 youth in oral health education and advocacy.

Under the leadership of Jackie Valadez, RDH, this year’s award winners demonstrated exceptional understanding of the issues pertaining to children’s dental health and wellness, while also holding an array of creative events to improve oral health literacy in their school and community. Specific activities included oral health educational presentations, social media advocacy, planting of Smile Gardens, and water demonstrations.

The awards, which include a $250 scholarship, will be presented at the HOSA 39th Annual International Leadership Conference in Nashville, TN, today. The students will also present highlights from their #MySmileMatters activities at a conference seminar for fellow HOSA students.

All #MySmileMatters participants utilize the #MySmileMatters National Youth Engagement Plan, which guides youth and their adult allies in integrating dental health education and learning into their schools and communities. The 2016-2017 National Youth Engagement Plan has the theme “Cavities are NOT Supposed to Happen” and focuses on “changing beliefs, changing behavior, and changing the environment” of children’s dental health and wellness. The National Youth Engagement Plan, available for free to all interested student groups, is available now at Contact or call (800) 559-9838 to learn more.



Day 3 of the Nobel Biocare Global Symposium

Posted on June 26, 2016

Highlights from Day 3 of the Nobel Biocare Global Symposium in New York City.

VIP Registration for SIROWORLD to Close on July 15

Posted on June 25, 2016

CHARLOTTE, N.C. (June 24, 2016) – Dentsply Sirona, the Dental Solutions Company™, announced today that due to overwhelming demand, VIP tickets to SIROWORLD: The Ultimate Dental Meeting from Aug. 11-13 at the Rosen Shingle Creek Resort in Orlando, Florida, will no longer be available after July 15, 2016.

Registration types for SIROWORLD vary, from doctor to dental technician to staff/spouse/guest to government and military, and more (visit for a full list of registration options). Regardless of attendees’ registration type, all registrants can upgrade to a VIP experience for an additional $500*.

VIP tickets to SIROWORLD include:

·       Exclusive VIP registration and lounge area.

·       Special seating during general sessions and entertainment events, including Jerry Seinfeld and OneRepublic.

·       VIP reception area during the SIROWORLD welcome reception, including special access to a reserved bar and special lounge seating.

·       Exclusive VIP area at the SIROWORLD closing party on Saturday evening, Aug. 13, and upgraded food and beverage options.

To register as a VIP to the ultimate dental meeting, visit, choose the applicable registration type and choose “VIP Upgrade” during the registration process. But hurry! Anyone who wishes to attend SIROWORLD as a VIP must register before July 15.

Many in the industry anticipate SIROWORLD to be the mecca of all dental events with thousands of dentists and dental professionals expected to attend. With up to 18 CE credits available to attendees, the education offered is invaluable. Eleven specialized tracks offer more than 100 educational breakout sessions from 95+ elite speakers within all fields of dentistry as well as marketing professionals and business leaders. 

To learn more about registering for SIROWORLD, visit Please contact our SIROWORLD help desk by emailing or calling 1-844-GO2-SIRO (1-844-462-7476) for additional questions.

*Please visit www.siroworld.comto view details on VIP upgrade options. 


Great Lakes Orthodontics Named 2016 Silver ESOP Award Winner

Posted on June 25, 2016

Great Lakes Orthodontics. Ltd., was recently named a 2016 Silver ESOP Award winner by The ESOP Association. The Silver ESOP Awards recognizes companies for their work in sustaining their ESOP (employee stock ownership plans) and Association memberships for 25 years or more.  Great Lakes was one of 26 corporate members of the Association to be honored with this award. The ESOP Association is the national trade association for companies with employee stock ownership plans and the leading voice in America for employee ownership.    

Great Lakes President James R. Kunkemoeller stated, “I am proud for all of our employee owners to be named a Silver ESOP Award recipient. Our commitment and dedication to the company and each other is a testament to the significant benefits of unified employee ownership.”

ESOP Association President J. Michael Keating stated, ”I consider it an honor and a statement of significance, to recognize Great Lakes. They are evidence that with proper management and planning, a company can remain employee owned, benefitting all employees for years to come.”     

Based in the Buffalo, New York, suburb of Tonawanda, Great Lakes Orthodontics is an employee-owned company specializing in products, laboratory services, and both in-house and online appliance fabrication training to members of the orthodontic, prosthodontic, restorative, and general dental professions worldwide. To learn more, visit


OSAP Announces New Boards of Directors

Posted on June 25, 2016

June 24, 2016 (ATLANTA, GA) — The Organization for Safety, Asepsis and Prevention (OSAP), a community of clinicians, educators, researchers and industry representatives who advocate for safe and infection-free delivery of oral healthcare, has announced the members of the 2016-2017 OSAP Board of Directors and the 2016-2017 OSAP Foundation Board of Directors.

The new OSAP Association Board is chaired by Mike Smurr, Director of Marketing, Merchandise, for Patterson Dental. Vice Chair is Kathy Eklund, Director of Infection Control and Occupational Health, and Research Subject and Patient Safety Advocate at Forsyth Institute in Boston. Dr. John O'Keefe, a general dentist who is Director of Knowledge Networks and Editor-in-Chief with the Canadian Dental Association, is the Immediate Past Chair. Marguerite Walsh, Vice President, Product Merchandising for Henry Schein Dental, will serve as Treasurer, and Karen Gregory, Director of Compliance and Education for Total Medical Compliance, will serve as Secretary.

Directors for the Association Board include Dr. Hudson Garrett, Global Chief Clinical Officer for Pentax Medical; Dr. Leslie Grant, Compliance Officer with the Maryland State Board of Dental Examiners; Dr. Theresa Mayfield, Associate Dean for Clinical Affairs at the University of Louisville School of Dentistry; Leanne Keefer, General Manager and Director of Education for Crosstex International; Dr. Doug Risk, Director of the USAF Dental Evaluation and Consultation Service; and Jessica Wilson, international speaker, trainer and educator for Hu-Friedy. Therese Long continues to serve on the board ex-officio. OSAP is a 501(c)(6) membership association. The purpose of the Association is to be the voice for leadership and compliance with science-based dental infection prevention and safety practices through quality education and information dissemination.

The OSAP Foundation Board will be chaired by Dr. Donald Marianos, a consultant in dental public health. Directors include Dr. Don Cohen, chief clinical officer, HealthFirst; Margaret (Peggy) Cottrell, President of ProEdge Dental (retired); Jennifer Naylor, General Manager, IMS and Infection Control Strategic Business Unit for Hu-Friedy Manufacturing; and Andrew (Andy) Whitehead, Vice President of Crosstex International. Therese Long continues to serve on the board ex-officio. The OSAP Foundation is a 501(c)(3) tax-exempt educational Foundation. The purpose of the Foundation is to augment and expand upon the Association’s ability to provide information and education by raising funds from the healthcare industry, private sector businesses, foundations and the government. The Foundation is dedicated to education, research, service, and policy development to promote safety and the control of infectious diseases in dental healthcare settings worldwide.


Addressing Antibiotic Resistance in Periodontal Treatment

Posted on June 25, 2016

June 22, 2016- For years the Centers for Disease Control and Prevention has been warning about the rise in antibiotic resistant bacteria and the challenges those bacteria pose to our health. In a recent publication on the website Perio-Implant Advisory, Dr. Duane Keller explains how bacteria become resistant to antibiotics and points a way to a non-antibiotic therapy for gum disease that follows the guidelines for chronic wound care and relies on oxidative and oxygenating agents.

Bacterial communities (biofilms) that cause infections leading to gum disease lie deep in periodontal pockets, the spaces between the teeth and gums which are hard to reach with toothbrush, rinse, or floss. The pocket is a unique space for chemotherapeutic modalities of care because it can be topically accessed, but keeping medicaments deep in the pocket for a significant amount of time was the most significant challenge for dentists until the invention of the Perio Tray® (Perio Protect, St. Louis, MO). 

While it looks a lot like a mouth guard, the Perio Tray® is specially fabricated with internal peripheral seals and extensions to place and hold medication deep in periodontal pockets.Research shows that the Perio Tray® can deliver medication into pockets as deep as 9mm (1-3mm is healthy). 

Hydrogen peroxide, even at a low concentration of 1.7%, has proven to be a highly effective antimicrobial when delivered and held deep in the pockets with the Perio Tray®. Peroxide can break down the protein chains in bacterial cell walls, lysing the cell wall and killing the bacterium. More importantly, the oxygen that the peroxide releases under the pressure of the Perio Tray® changes the micro-environment of the periodontal pocket. The oxygen is toxic to anaerobes, helps promote a healthy oral flora, and fosters growth of new blood vessels.

All of this is good news for the millions of patients (47% of American adults) with chronic gum disease. In combination with professional dental cleanings, the Perio Tray® with 1.7% hydrogen peroxide is only needed for minutes each day. When it is used at home between professional dental cleanings, the Perio Tray® delivery of peroxide puts biofilm communities on the defensive, limiting their ability to reproduce and trigger inflammation and leading to better long-term results. 

For more information on the Perio Tray® by Perio Protect, visit


Day 2 of Nobel Biocare Global Symposium

Posted on June 25, 2016

Day 2 of the Nobel Biocare Global Symposium

Highlights from Day One at the Nobel Biocare Global Symposium

Posted on June 24, 2016

Tony Angelini, president of AEGIS Communications, shares highlights from the first day of the Nobel Biocare Global Symposium.

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