A New Era in Periodontal and Peri-Implant Regeneration: Use of Growth-Factor Enhanced Matrices Incorporating rhPDGF

Abstract

A new and powerful off-the-shelf bone and tissue regeneration technology termed Growth-Factor Enhanced Matrix has recently become available for clinical use. This graft material consists of a concentrated solution of pure recombinant human platelet-derived growth factor (rhPDGF-BB), the synthetic form of the body's key natural wound healing stimulator PDGF-BB, and an osteoconductive (bone scaffold) matrix. This if the first purified, recombinant (synthetic) growth factor product to be commercially available and is the result of over a decade of extensive research. Clinical and animal study results with this graft material demonstrate that it is capable of simultaneously promoting regeneration of bone and accelerating soft-tissue attach,ent gain in challenging periodontal and periimplant defects.