With the multitude of choices for all-ceramic restorations on the market today, many questions can arise clinically. This clearly becomes evident when it is time to cement the restoration. Does the restoration need to be adhesively bonded to increase its strength or can you use conventional luting cements? Does the intaglio surface of the restoration need to be etched? Does it need to be silanated? It is the intent of this article to answer the previous questions and discuss the options for cementation of high-strength zirconia restorations in clinical practice.